Portfolio

Mamyzin Boehringer Ingelheim 
Ester of benzylpenicillin for subcutaneous or intramuscular injection

Composition and Presentation:
Mamyzin® is the trade name of penethamate hydriodide an ester of benzylpenicillin.
Each clear glass vial contains penethamate hydriodide as an off-white sterile powder for reconstituting using the enclosed water for injection. 5 g and 10 g of penethamate hydriodide are equivalent to 5 million i.u. and 10 million i.u.
of benzylpenicillin (penicillin G) respectively.
Actions:
Penethamate hydriodide as an ester is lipophilic and basic. It has a special ability to diffuse through cell membranes securing a rapid and even distribution throughout the tissue of the target organ. It is particularly suitable for the treatment of infections of the mammary, respiratory and uterine tissue.
Pharmacokinetic Properties:
Mamyzin® (penethamate hydriodide) protects and conveys the benzylpenicillin intact to the focus of infection where it is released to exert its bactericidal effect. Unlike the other commonly used parenteral penicillins, Mamyzin® is a salt of a
weak base (pKa 8.5), therefore a high proportion of Mamyzin® appears in the plasma and tissue in a nonionised form. It has a special ability to diffuse through cell membranes, endothelia and tissue barriers, to the focus of infection where it
is hydrolysed to the therapeutically active benzylpenicillin.
Warning
This product contains an ester of benzylpenicillin.
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact.
Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
Indications:
Mamyzin® is indicated for the treatment of infections caused by gram-positive bacteria that cause mastitis, respiratory infections, footrot and uterine infections.
Mastitis Therapy:
The levels of penicillin in the milk following an injection of Mamyzin® are about 10 times higher than the levels following injection of other benzylpenicillin preparations at an equivalent dose. The pharmacokinetic properties of
Mamyzin® ensure penetration of the mammary tissue even in inflamed quarters, with high penicillin concentrations achieved at the site of the infection. These properties make Mamyzin®suitable for systemic penicillin therapy in acute and subacute mastitis.

Mamyzin Boehringer Ingelheim